Implants temporarily or permanently replace tissue that is damaged or impaired in its function. Intolerance to certain implant materials can trigger local inflammatory reactions. These are based on cell-type-specific signaling pathways and can trigger chronic foreign body reactions, which are further exacerbated by degradation products of the materials.
In this context, Research Training Group 2901 SYLOBIO, funded by the German Research Foundation (DFG), investigates local and systemic reactions to implant materials. The goal is to comprehensively characterize the complex inflammatory processes and patient-specific differences in tissue response using a multidisciplinary approach.

Metallic wear and corrosion products can significantly influence cellular processes. Certain metal ions, such as cobalt (Co²⁺), activate the hypoxia-inducible factor HIF-1α, which influences metabolism, angiogenesis, and cell differentiation. At the same time, corrosion products can trigger oxidative stress and thereby exacerbate inflammatory reactions.
The project investigates how human mesenchymal stem/stromal cells and endothelial cells respond to such metallic components. The focus is on changes in differentiation status, the expression of Toll-like receptors, and the release of extracellular vesicles.
In co-cultures, the project also analyzes how metal abrasion influences the interaction between the two cell types and their angiogenesis potential. The goal is to better understand how metallic components regulate regeneration and immune responses in an inflammatory environment.