Working group Cellular Adhesion

The primary assessment criterion for the usability of new biomaterials is the biocompatibility, representing the ability to function at their desired location in an organism. Current challenges in the field of biomaterial research go beyond this and deal with bioactive materials which are able to specifically influence the tissue surrounding them, e.g. to induce regeneration. Requirements for the materials are therefore the ability to regulate cell proliferation, differentiation, and migration. Detailed information about molecular interactions between the biomaterial and the biosystem are of great importance in this context. Especially integrin receptors play an important role for the cell-matrix or cell-material contact, as they are essential for cell regulation in biological tissue. The extracellular matrix is a complex network, consisting of macromolecules such as proteins (e.g. collagen, fibronectin, laminin) and polysaccharides (e.g. glucosaminoglycans). These macromolecules are produced by the cells themselves and transported into the intercellular space.

The focus is on the following topics:

One focus is on primary cellular mechanisms at the interface to topographically and chemically modified biomaterials – cell-biomaterial interaction:

  • Integrin-mediated cell adhesion
  • Signal transduction via integrin receptors
  • Intracellular calcium signaling
  • Time-dependent analysis of actin cytoskeleton assembly
  • Regulation of cell functions, migration, growth, differentiation at the interface
  • Mathematical correlation of physico-chemical parameters of the material to cellular parameters
  • Quantification of confocal microscopy images
  • Modelling of the biosystem-material interaction

Another focus is on the transmission of mechanical stimuli via integrin receptors – Mechanotransduction:

  • Differentiation of stem cells by mechanical stimuli
  • Calcium mobilisation and phosphorylation of signal proteins
  • Simultaneous influence of drugs and mechanical stimuli

A new focus of our research is the analysis of cell physiology under physical stimuli such as atmospheric pressure plasma and electrostimulation:

  • Organization of cell-cell-contacts
  • Proliferation and apoptosis
  • Translocation of cellular structures
  • Cell morphology , cytotoxicity

[Translate to English:] Kooperationspartner, extern:

Leibniz-Institut für Plasmaforschung und Technologie e. V. (INP)
Greifswald, D
www.inp-greifswald.de

Prof. Dr. Klaus-Dieter Weltmann,
Prof. Dr. Thomas von Woedtke,
Dr. Frank Hempel

 

Institut de Sciences des Materiaux de Mulhouse (IS2M)
Frankreich
www.is2m.uha.fr

Dr. Karine Anselme

INNOVENT e.V.
Jena, D
www.innovent-jena.de

Dr. Matthias Schnabelrauch

Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie/Plastische Operationen
Universitätsmedizin Greifswald

Coat-X AG, Switzerland

 

News

IBI 2024

[Translate to English:] Landesexzellenzprojekt ONKOTHER-H

Digital Meeting of GraduiertenVerbundAkademie (GVA)

Book "Materials for Medical Application"

(Editor: Robert B. Heimann, publishing house De Gruyter) published: