Working group Cellular Adhesion

[Translate to English:] Zelluläre Adhäsion

The primary assessment criterion for the usability of new biomaterials is the biocompatibility, representing the ability to function at their desired location in an organism. Current challenges in the field of biomaterial research go beyond this and deal with bioactive materials which are able to specifically influence the tissue surrounding them, e.g. to induce regeneration. Requirements for the materials are therefore the ability to regulate cell proliferation, differentiation, and migration. Detailed information about molecular interactions between the biomaterial and the biosystem are of great importance in this context. Especially integrin receptors play an important role for the cell-matrix or cell-material contact, as they are essential for cell regulation in biological tissue. The extracellular matrix is a complex network, consisting of macromolecules such as proteins (e.g. collagen, fibronectin, laminin) and polysaccharides (e.g. glucosaminoglycans). These macromolecules are produced by the cells themselves and transported into the intercellular space.

The focus is on the following topics:

One focus is on primary cellular mechanisms at the interface to topographically and chemically modified biomaterials – cell-biomaterial interaction:

  • Integrin-mediated cell adhesion
  • Signal transduction via integrin receptors
  • Intracellular calcium signaling
  • Time-dependent analysis of actin cytoskeleton assembly
  • Regulation of cell functions, migration, growth, differentiation at the interface
  • Mathematical correlation of physico-chemical parameters of the material to cellular parameters
  • Quantification of confocal microscopy images
  • Modelling of the biosystem-material interaction

Another focus is on the transmission of mechanical stimuli via integrin receptors – Mechanotransduction:

  • Differentiation of stem cells by mechanical stimuli
  • Calcium mobilisation and phosphorylation of signal proteins
  • Simultaneous influence of drugs and mechanical stimuli

A new focus of our research is the analysis of cell physiology under physical stimuli such as atmospheric pressure plasma and electrostimulation:

  • Organization of cell-cell-contacts
  • Proliferation and apoptosis
  • Translocation of cellular structures
  • Cell morphology , cytotoxicity

[Translate to English:] Kooperationspartner, extern:

[Translate to English:] logo INP

Leibniz-Institut für Plasmaforschung und Technologie e. V. (INP)
Greifswald, D
www.inp-greifswald.de

Prof. Dr. Klaus-Dieter Weltmann,
Prof. Dr. Thomas von Woedtke,
Dr. Frank Hempel

 

[Translate to English:] logo IS2M

Institut de Sciences des Materiaux de Mulhouse (IS2M)
Frankreich
www.is2m.uha.fr

Dr. Karine Anselme

[Translate to English:] logo INNOVENT

INNOVENT e.V.
Jena, D
www.innovent-jena.de

Dr. Matthias Schnabelrauch

[Translate to English:] Logo UMG

Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie/Plastische Operationen
Universitätsmedizin Greifswald

[Translate to English:] Logo COAT-X AG

Coat-X AG, Switzerland

 

News

Book "Materials for Medical Application"

(Editor: Robert B. Heimann, publishing house De Gruyter) published:

[Translate to English:] Heimann 2020