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PD Dr. Kirsten Peters

Stellvertr. Leiterin des Arbeitsbereichs Zellbiologie

Telefon: 0381 - 494 7757 / 7774

E-mail: kirsten.peters{bei}med.uni-rostock.de

Adresse:
Universität Rostock
Universitätsmedizin Rostock
Arbeitsbereich Zellbiologie
Schillingallee 69
18057 Rostock

Curriculum Vitae:

  Studium und akademische Laufbahn
2010 Umhabilitation an die Universitätsmedizin Rostock, Venia legendi für das Fach "Zellbiologie"
2008 Habilitation an der Medizinischen Fakultät der Johannes Gutenberg-Universität Mainz, Venia legendi für das Fach "Molekulare Medizin"
seit Okt. 2006 Leiterin der Nachwuchsgruppe "Stammzelldifferenzierung", Universität Rostock, Arbeitsbereich Zellbiologie (Prof. Dr. J. Rychly)
1999 - 2006 Wissenschaftliche Mitarbeiterin/Post-Doc am Institut für Pathologie der Johannes Gutenberg-Universität Mainz (Prof. Dr. C.J. Kirkpatrick)
1997 - 1999 Wissenschaftliche Mitarbeiterin/Post-Doc am Institut für Arterioskleroseforschung, WWU Münster; Bereich "Molekulare Kardiologie" (Prof. Dr. G. Breithardt, PD Dr. A. Skaletz-Rorowski)
1994 - 1998 Dissertation am Institut für Arterioskleroseforschung, WWU Münster, Bereich "Biochemie der Arterienwand" (Prof. Dr. J. Rauterberg) Dissertationsthema: "Induktion von Angiogenese in vitro durch Kollagen und Fibrin"
1993 - 1994 Diplomarbeit am Institut für Zoophysiologie, WWU Münster, (Prof. Dr. G. Kamp), "Charakterisierung von Phosphagensystemen in Nereiden"
1992 - 1994 Studentische Hilfskraft am Institut für Zoophysiologie, WWU Münster (Prof. Dr. G. Kamp)
1985 - 1994 Biologiestudium an der Westfälischen Wilhelms-Universität (WWU) Münster
  1. Van Nieuwenhove I*, Salamon A*, Adam S, Dubruel P, Van Vlierberghe S, Peters K: Gelatin- and starch-based hydrogels. Part B: In vitro mesenchymal stem cell behavior on the hydrogels. Carbohydrate Polymers 2017;161:295–305. DOI: 10.1016/j.carbpol.2017.01.010. (*both authors contributed equally)
  2. Kieb, M, Sander F, Prinz C, Adam S, Mau-Möller A, Bader R, Peters K, Tischer T: Platelet-rich plasma powder: A new preparation method for the standardization of growth factors concentrations. American Journal of Sports Medicine 2016;45(4)954-960. DOI: 10.1177/0363546516674475
  3. Herzmann N, Salamon A, Fiedler T, Peters K: Lipopolysaccharide induces proliferation and osteogenic differentiation of adipose-derived mesenchymal stromal cells in vitro via TLR4 activation. Experimental Cell Research 2016;350(1):115-122. DOI: 10.1016/j.yexcr.2016.11.012
  4. Van Nieuwenhove I, Salamon A, Peters K, Graulus GJ, Martins JC, Frankel D, Kersemans K, De Vos F, Van Vlierberghe S, Dubruel P: Gelatin- and starch-based hydrogels. Part A: Hydrogel development, characterization and coating. Carbohydrate Polymers 2016;152:129–139. DOI: 10.1016/j.carbpol.2016.06.098
  5. Herzmann N, Salamon A, Fiedler T, Peters K: Analysis of migration rate and chemotaxis of human adipose-derived mesenchymal stem cells in response to LPS and LTA in vitro. Experimental Cell Research 2016, 15;342(2):95-103. DOI: 10.1016/j.yexcr.2016.03.016
  6. Wollank Y, Ramer R, Ivanov I, Salamon A, Peters K, Hinz B: Inhibition of FAAH confers increased stem cell migration via PPARα. J Lipid Res. 2015; 56(10): 1947-1960. DOI: 10.1194/jlr.M061473
  7. Van Nieuwenhove I, Van Vlierberghe S, Salamon A, Peters K, Thienpont H, Dubruel P: Photo-crosslinkable biopolymers targeting stem cell adhesion and proliferation: the case study of gelatin and starch-based IPNs. J Mater Sci: Mater Med. 2015;26(2). DOI: 10.1007/s10856-015-5424-4
  8. Tsaryk R, Bartholomä NM, Simiantonaki N, Anspach L, Peters K, Heilmann C, Kirkpatrick CJ, Pröls F: Endoplasmic reticulum-resident chaperones modulate the inflammatory and angiogenic responses of endothelial cells. Br J Dermatol. 2015; 173(2):416-427. DOI: 10.1111/bjd.13816.
  9. Meyer J, Salamon A, Herzmann N, Adam S, Kleine HD, Matthiesen I, Ueberreiter K, Peters K: Isolation and differentiation potential of human mesenchymal stem cells from adipose tissue harvested by water jet-assisted liposuction. Aesthet Surg J. 2015;35(8):1030-1039. DOI: 10.1093/asj/sjv075.
  10. Bulnheim U, Muller P, Neumann HG, Peters K, Unger RE, Kirkpatrick CJ, Rychly J. Endothelial cells stimulate osteogenic differentiation of mesenchymal stem cells on calcium phosphate scaffolds. Journal of tissue engineering and regenerative medicine 2014;8(10):831-840. DOI: 10.1002/term.1590
  11. Salamon A, Adam S, Rychly J, Peters K. Long-term tumor necrosis factor treatment induces NFkappaB activation and proliferation, but not osteoblastic differentiation of adipose tissue-derived mesenchymal stem cells in vitro. The international journal of biochemistry & cell biology 2014;54:149-162. DOI: 10.1016/j.biocel.2014.07.014
  12. Salamon A, van Vlierberghe S, van Nieuwenhove I, Baudisch F, Graulus GJ, Benecke V, Alberti K, Neumann HG, Rychly J, Martins JC, Dubruel P, Peters K. Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro. Materials 2014;7(2):1342-1359. DOI: 10.3390/ma7021342
  13. Schmuhl E, Ramer R, Salamon A, Peters K, Hinz B. Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK. Biochemical pharmacology 2014;87(3):489-501. DOI: 10.1016/j.bcp.2013.11.016
  14. Unger RE, Peters K, Sartoris A, Freese C, Kirkpatrick CJ. Human endothelial cell-based assay for endotoxin as sensitive as the conventional Limulus Amebocyte Lysate assay. Biomaterials 2014;35(10):3180-3187. DOI: 10.1016/j.biomaterials.2013.12.059
  15. Waser-Althaus J, Salamon A, Waser M, Padeste C, Kreutzer M, Pieles U, Muller B, Peters K. Differentiation of human mesenchymal stem cells on plasma-treated polyetheretherketone. Journal of materials science - Materials in medicine 2014;25(2):515-525. DOI: 10.1007/s10856-013-5072-5
  16. Pasold J, Osterberg A, Peters K, Taipaleenmaki H, Saamanen AM, Vollmar B, Muller-Hilke B. Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis in STR/ort mice. Experimental cell research 2013;319(5):649-659. DOI: 10.1016/j.yexcr.2012.12.012
  17. Fiedler T, Salamon A, Adam S, Herzmann N, Taubenheim J, Peters K. Impact of bacteria and bacterial components on osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells. Experimental cell research 2013;319(18):2883-2892. DOI: 10.1016/j.yexcr.2013.08.020
  18. Salamon A, Jonitz-Heincke A, Adam S, Rychly J, Muller-Hilke B, Bader R, Lochner K, Peters K. Articular cartilage-derived cells hold a strong osteogenic differentiation potential in comparison to mesenchymal stem cells in vitro. Experimental cell research 2013;319(18):2856-2865. DOI: 10.1016/j.yexcr.2013.09.008
  19. Tsaryk R, Peters K, Barth S, Unger RE, Scharnweber D, Kirkpatrick CJ. The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6Al4V alloy. Biomaterials 2013;34(33):8075-8085. DOI: 10.1016/j.biomaterials.2013.07.030
  20. Tsaryk R, Peters K, Unger RE, Feldmann M, Hoffmann B, Heidenau F, Kirkpatrick CJ. Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells. Journal of the Royal Society, Interface 2013;10(86):20130428. DOI: 10.1098/rsif.2013.0428
  21. Peters K, Prinz C, Salamon A, Rychly J, Neumann HG. In vitro evaluation of cytocompatibility of shellac as coating for intravascular devices. Trends in Biomaterials and Artifical Organs 2012;26(2):110-113.
  22. Jonitz A, Lochner K, Peters K, Salamon A, Pasold J, Mueller-Hilke B, Hansmann D, Bader R. Differentiation capacity of human chondrocytes embedded in alginate matrix. Connective tissue research 2011;52(6):503-511. DOI: 10.3109/03008207.2011.593673
  23. Peters K, Unger RE, Kirkpatrick CJ. Biocompatibility testing. In: Biomedical Materials. Ed.: Narayan R. 2009, pp 261-292
  24. Peters K, Salamon A, Van Vlierberghe S, Rychly J, Kreutzer M, Neumann HG, Schacht E, Dubruel P. A new approach for adipose tissue regeneration based on human mesenchymal stem cells in contact to hydrogels - an in vitro study. Advanced engineering materials 2009;11(10):B155-B161. DOI: 10.1002/adem.200800379
  25. Campillo-Fernandez AJ, Unger RE, Peters K, Halstenberg S, Santos M, Salmeron Sanchez M, Meseguer Duenas JM, Monleon Pradas M, Gomez Ribelles JL, Kirkpatrick CJ. Analysis of the biological response of endothelial and fibroblast cells cultured on synthetic scaffolds with various hydrophilic/hydrophobic ratios: influence of fibronectin adsorption and conformation. Tissue engineering Part A 2009;15(6):1331-1341. DOI: 10.1089/ten.tea.2008.0146
  26. Peters K, Kamp G, Berz A, Unger RE, Barth S, Salamon A, Rychly J, Kirkpatrick CJ. Changes in human endothelial cell energy metabolic capacities during in vitro cultivation. The role of "aerobic glycolysis" and proliferation. Cellular physiology and biochemistry 2009;24(5-6):483-492. DOI: 10.1159/000257490
  27. Peters K, Unger RE, Stumpf S, Schafer J, Tsaryk R, Hoffmann B, Eisenbarth E, Breme J, Ziegler G, Kirkpatrick CJ. Cell type-specific aspects in biocompatibility testing: the intercellular contact in vitro as an indicator for endothelial cell compatibility. Journal of materials science - Materials in medicine 2008;19(4):1637-1644. DOI: 10.1007/s10856-007-3227-y
  28. Santos MI, Tuzlakoglu K, Fuchs S, Gomes ME, Peters K, Unger RE, Piskin E, Reis RL, Kirkpatrick CJ. Endothelial cell colonization and angiogenic potential of combined nano- and micro-fibrous scaffolds for bone tissue engineering. Biomaterials 2008;29(32):4306-4313. DOI: 10.1016/j.biomaterials.2008.07.033
  29. Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI, Kirkpatrick CJ. Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines. International journal of oncology 2008;32(3):585-592.
  30. Kalbacova M, Roessler S, Hempel U, Tsaryk R, Peters K, Scharnweber D, Kirkpatrick JC, Dieter P. The effect of electrochemically simulated titanium cathodic corrosion products on ROS production and metabolic activity of osteoblasts and monocytes/macrophages. Biomaterials 2007;28(22):3263-3272. DOI: 10.1016/j.biomaterials.2007.02.026
  31. Kirkpatrick CJ, Fuchs S, Hermanns I, Peters K, Unger RE. Cell culture models of higher complexitiy in tissue engineering and regenerative medicine. Biomaterials 2007;28(34):5193-5198. DOI: 10.1016/j.biomaterials.2007.08.012
  32. Tsaryk R, Peters K, Unger RE, Scharnweber D, Kirkpatrick CJ. The effects of metal implants on inflammatory and healing processes. Internation journal of materials research 2007;98(7):622-629. DOI: 10.3139/146.101508
  33. Peters K, Unger RE, Gatti AM, Sabbioni E, Tsaryk R, Kirkpatrick CJ. Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro. International journal of immunopathology and pharmacology 2007;20(4):685-695.
  34. Tsaryk R, Kalbacova M, Hempel U, Scharnweber D, Unger RE, Dieter P, Kirkpatrick CJ, Peters K. Response of human endothelial cells to oxidative stress on Ti6Al4V alloy. Biomaterials 2007;28(5):806-813. DOI: 10.1016/j.biomaterials.2006.09.033
  35. Unger RE, Sartoris A, Peters K, Motta A, Migliaresi C, Kunkel M, Bulnheim U, Rychly J, Kirkpatrick CJ. Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials. Biomaterials 2007;28(27):3965-3976. DOI: 10.1016/j.biomaterials.2007.05.032
  36. Peters K, Schmidt H, Kamp G, Unger RE, Hoffmann B, Stenzel F, Ziegler G, Jung M, Stumpf S, Kirkpatrick CJ. Software-supported quantification of angiogenesis in an in vitro culture system. Examples of applications in studies of basic research, biocom¬patibility and drug discovery. In: Trends in angiogenesis research, Ed.: Zubar RV. 2005, pp. 103-123
  37. Kirkpatrick CJ, Fuchs S, Peters K, Brochhausen C, Hermanns MI, Unger RE. Visions for regenerative medicine: interface between scientific fact and science fiction. Artificial organs 2006;30(10):822-827. DOI: 10.1111/j.1525-1594.2006.00306.x
  38. Kirkpatrick CJ, Peters K, Fuchs S, Unger RE. Titanium in the age of tissue engineering: Challenges and opportunities. Rare metal materials and engineering 2006;35(Suppl.1):273-276.
  39. Peters K, Unger RE, Gatti AM, Sabbioni E, Gambarelli A, Kirkpatrick CJ. Impact of ceramic and metallic nano-scaled particles on endothelial cell functions in vitro. In: Nanomaterials – Toxicity, health and environmental issues. Ed.: Kumar CSSR. 2006, pp. 108-129
  40. Hoffmann B, Kokott A, Shafranska O, Detsch R, Winter S, Eisenbarth E, Peters K, Breme J, Kirkpatrick CJ, Ziegler G. [Corrosion behaviour, metal release and biocompatibility of implant materials coated by TiO2-sol gel chemistry]. Biomedical engineering - Biomedizinische Technik 2005;50(10):320-329. DOI: 10.1515/BMT.2005.045
  41. Peters K, Schmidt H, Unger RE, Kamp G, Prols F, Berger BJ, Kirkpatrick CJ. Paradoxical effects of hypoxia-mimicking divalent cobalt ions in human endothelial cells in vitro. Molecular and cellular biochemistry 2005;270(1-2):157-166. DOI: 10.1007/s11010-005-4504-z
  42. Unger RE, Huang Q, Peters K, Protzer D, Paul D, Kirkpatrick CJ. Growth of human cells on polyethersulfone (PES) hollow fiber membranes. Biomaterials 2005;26(14):1877-1884. DOI: 10.1016/j.biomaterials.2004.05.032
  43. Unger RE, Peters K, Huang Q, Funk A, Paul D, Kirkpatrick CJ. Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes. Biomaterials 2005;26(17):3461-3469. DOI: 10.1016/j.biomaterials.2004.09.047
  44. Hermanns MI, Unger RE, Kehe K, Peters K, Kirkpatrick CJ. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. Laboratory investigation; a journal of technical methods and pathology 2004;84(6):736-752. DOI: 10.1038/labinvest.3700081
  45. Peters K, Unger RE, Kirkpatrick CJ, Gatti AM, Monari E. Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation. Journal of materials science - Materials in medicine 2004;15(4):321-325. DOI: 10.1023/B:JMSM.0000021095.36878.1b
  46. Unger RE, Peters K, Wolf M, Motta A, Migliaresi C, Kirkpatrick CJ. Endothelialization of a non-woven silk fibroin net for use in tissue engineering: growth and gene regulation of human endothelial cells. Biomaterials 2004;25(21):5137-5146. DOI: 10.1016/j.biomaterials.2003.12.040
  47. Unger RE, Wolf M, Peters K, Motta A, Migliaresi C, Kirkpatrick CJ. Growth of human cells on a non-woven silk fibroin net: a potential use in tissue engineering. Biomaterials 2004;25(6):1069-1075. DOI: 10.1016/S0142-9612(03)00619-7
  48. Peters K, Unger RE, Brunner J, Kirkpatrick CJ. Molecular basis of endothelial dysfunc¬tion in sepsis. Cardiovasc Res 2003;60(1):49-57. DOI: 10.1016/S0008-6363(03)00397-3
  49. Berger BJ, Muller TS, Buschmann IR, Peters K, Kirsch M, Christ B, Prols F. High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells. Experimental cell research 2003;290(1):82-92. DOI: 10.1016/S0014-4827(03)00316-1
  50. Kirkpatrick CJ, Unger RE, Krump-Konvalinkova V, Peters K, Schmidt H, Kamp G. Experimental approaches to study vascularization in tissue engineering and biomaterial applications. Journal of materials science - Materials in medicine 2003;14(8):677-681. DOI: 10.1023/A:1024903514335
  51. Kirkpatrick CJ, Peters K, Hermanns MI, Krump-Konvalinkova V, Unger RE. Using endothelial cell cultures to study implant vascularisation. In: Materials in clincial appli¬cations VI, Eds: Vincenzini P, Barbucci R. CIMTEC 2002, pp. 335-346
  52. Kirkpatrick CJ, Barth S, Gerdes T, Krump-Konvalinkova V, Peters K. Pathomechanismen der gestörten Wunheilung durch metallische Korrosionsprodukte. Mund-, Kiefer- und Gesichtschirurgie: MKG 2002;6:183-190.
  53. Kirkpatrick CJ, Krump-Konvalinkova V, Unger RE, Bittinger F, Otto M, Peters K. Tissue response and biomaterial integration: the efficacy of in vitro methods. Biomolecular engineering 2002;19(2-6):211-217. DOI: 10.1016/S1389-0344(02)00019-9
  54. Peters K, Schmidt H, Unger RE, Otto M, Kamp G, Kirkpatrick CJ. Software-supported image quantification of angiogenesis in an in vitro culture system: application to studies of biocompatibility. Biomaterials 2002;23 (16):3413-3419. DOI: 10.1016/S0142-9612(02)00042-X
  55. Peters K, Troyer D, Kummer S, Kirkpatrick CJ, Rauterberg J. Apoptosis causes lumen formation during angiogenesis in vitro. Microvascular research 2002;64(2):334-338. DOI: 10.1006/mvre.2002.2438
  56. Unger RE, Krump-Konvalinkova V, Peters K, Kirkpatrick CJ. In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R. Microvascular research 2002;64(3):384-397. DOI: 10.1006/mvre.2002.2434
  57. Krump-Konvalinkova V, Bittinger F, Unger RE, Peters K, Lehr HA, Kirkpatrick CJ. Generation of human pulmonary microvascular endothelial cell lines. Laboratory investigation; a journal of technical methods and pathology 2001;81:1717-1727.
  58. Peters K, Unger RE, Barth S, Gerdes T, Kirkpatrick CJ. Induction of apoptosis in human microvascular endothelial cells by divalent cobalt ions. Evidence for integrin-mediated signaling via the cytoskeleton. Journal of materials science - Materials in medicine 2001;12(10-12):955-958. DOI: 10.1023/A:1012852814570

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